About us

University Hospital of Psychiatry and Psychotherapy
Translational Research Center (TRC) 
Division of Systems Neuroscience of Psychopathology

The commonly used traditional diagnostic classification systems for psychiatric disorders are increasingly recognized to be one of the reasons for a lack of innovation and development in psychiatry. It is gradually accepted that psychopathology, e.g. specific symptoms can be observed across clinical diagnosis and have a dimensional aspect. It seems necessary to focus more strongly on the specific link between specific psychopathology – symptoms – and large-scale brain systems to improve the understanding of mental disorder and consequently to develop more efficient treatments and result in a progress of prediction of illness course and prevention in psychiatry. This endeavor is the aim of the Synopsis project at the University Hospital of Psychiatry.


Group Walther

Our mission is to apply translational research methods in order to understand abnormal behavior in psychiatric disorders. The ultimate goal is to turn knowledge on the pathobiology of behavior into starting points for the development of individualized treatment options. Our research focuses on abnormalities of communication processes in affective disorders and the psychosis spectrum. We aim to improve social integration, real-world functioning, and quality of life of our patients.


Group Stegmayer

Defective emotional regulation is a central feature of psychiatric disorders, suggested as a determinant for functional outcome. Importantly, emotional dysregulation is in some cases hard to detect in the clinical interview, which hampers to investigate the underlying pathophysiology. The aim of our research is to disentangle the underlying neurobiology of emotional dysregulation. Our eventual dream is to effectively improve the diagnosis and treatment of mental disorders in order to improve patient’s lives. In our view, this would need a great effort of translational research bridging neurobiological, clinical, psychiatric research and more methodologically oriented, basic scientific research.


Group Hubl

The group interests cover clinical and scientific topics. Clinical activities could be allocated to Hubl Daniela. Scientific activities could be allocated additional to Hubl Daniela to Dierks Thomas and Koenig Thomas.


From Health to Psychosis


According to previous work in the course of the Systems Neuroscience of Psychosis (SyNoPsis) project, psychotic symptoms represent disturbances in higher-order brain functions in the domains of language, emotion, and motor function. They can be grouped with regard to underlying dysfunctions of three distinct, anatomically and functionally segregated brain circuitries, namely the brain’s language, limbic and motor systems with their cortico-basal and cortico-cortical circuitries. In this research group, we extend the SyNoPsis framework to the healthy population, investigating the interaction of behavioral functions in these three domains and their respective underlying brain circuitries. Therewith, we aim at providing further evidence for the validity of the continuum hypothesis of psychopathology for psychotic disorders. These findings will be important to identify disease mechanisms underlying distinct subtypes of psychosis and may stimulate future research on novel diagnostic classification approaches as well as on symptom-specific treatment.